Studying Rhesus Cytomegalovirus (RhCMV) to Develop Therapeutics for Human Cytomegalovirus (HCMV)


  • Naomi Akhidenor Texas Woman's University


HCMV, RhCMV, GPCR, US28, Cytomegalovirus


Cytomegalovirus (CMV) is an evolutionarily divergent virus with unique species specificity limiting its ability to infect multiple hosts. The form of the virus specific to humans is known as human cytomegalovirus (HCMV). HCMV possesses pathogenic significance especially in immunocompromised individuals. As there remains a need to explore HCMV, limitations arise from the host restriction and inability to conduct vaccine development studies in human hosts. Rhesus Cytomegalovirus (RhCMV) is another opportunistic virus naturally isolated in Rhesus macaques and it contains most of HCMV gene families. In this review, primary research articles were sourced for information to better understand the relationship between HCMV and RhCMV. It explores how studying RhCMV in its natural host presents a preeminent model for the prevention of HCMV infection and will aid in the development of vaccines and therapeutics.



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How to Cite

Akhidenor, N. (2021). Studying Rhesus Cytomegalovirus (RhCMV) to Develop Therapeutics for Human Cytomegalovirus (HCMV). TWU Student Journal, 1(1), 7–15. Retrieved from